There as been some concern regarding the nutritional supplement NO Explode and whether its use as a stimulant has any adverse effects on the heart. NO Explode is an ephedra free nutritional supplement, and the only ingredient it contains that is classified as a stimulant is caffeine. If you are taking the supplement as directed, you will only have caffeine equal to about 2 cups of coffee and measured at about 200 mg. Your body sees an increase in activity of the cells and sends a message from to the adrenal gland to produce adrenaline. The release of adrenaline causes the heart rate to increase, the liver releases more sugar and this allows for a release of energy. By conforming to the recommended dosage you will be able to safely and effectively benefit from the use of the nutritional supplement.